The ester hydrolysis reaction, using tetrabutylammonium fluoride trihydrate [0.05 M TBAF·3H2O in N,N-dimethylformamide (DMF), 25°C, 30 min, twice], has been successfully applied to the removal of a peptide chain from a solid phase resin support.
M. Ueki, K. Kai, M. Amemiya, H. Horino and H. Oyamada, J. Chem. Soc., Chem. Commun., 1988, 414 DOI: 10.1039/C39880000414
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