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Issue 2, 1984
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Photo-oxidation of 6-mercaptopurine in aqueous solution


Irradiation of oxygenated aqueous solutions of 6-mercaptopurine with near-u.v. light leads to purine-6-sulphinate as primary product. The sulphinate is itself unstable to u.v. light and is further oxidized to purine-6-sulphonate. Hypoxanthine is a minor product (<10%) of direct photolysis, but also arises from degradation of the sulphonate. Sensitized photo-oxidation using dyes (Methylene Blue, Rose Bengal, or Rhodamine B) gives the same products, and reaction in D2O occurs at a greater rate, indicating that the primary photoreaction occurs via addition of singlet molecular oxygen.

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Article type: Paper
DOI: 10.1039/P29840000209
Citation: J. Chem. Soc., Perkin Trans. 2, 1984, 209-211
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    Photo-oxidation of 6-mercaptopurine in aqueous solution

    V. J. Hemmens and D. E. Moore, J. Chem. Soc., Perkin Trans. 2, 1984, 209
    DOI: 10.1039/P29840000209

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