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Issue 0, 1984
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The biosynthesis of rubrofusarin, a polyketide naphthopyrone from Fusarium culmorum: 13C n.m.r. assignments and incorporation of 13C- and 2H-labelled acetates

Abstract

The polyketide chain in rubrofusarin biosynthesis has been shown to adopt the folding pattern B by the incorporation of 13CH313CO2 Na and of CD313CO2 Na, with observation of the β-isotopic shifts in the 13C n.m.r. spectrum, in the rubrofusarin derivative (5). The extent of retention of deuterium at the various sites is interpreted in terms of an unusual sequence of biosynthetic steps. The assignment of the 13C n.m.r. spectrum of rubrofusarin dimethyl ether (2) was made with the aid of specific deuteriation and 1H–13C n.O.e.'s as well as more standard techniques.

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Article type: Paper
DOI: 10.1039/P19840002919
Citation: J. Chem. Soc., Perkin Trans. 1, 1984,0, 2919-2925
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    The biosynthesis of rubrofusarin, a polyketide naphthopyrone from Fusarium culmorum: 13C n.m.r. assignments and incorporation of 13C- and 2H-labelled acetates

    F. J. Leeper and J. Staunton, J. Chem. Soc., Perkin Trans. 1, 1984, 0, 2919
    DOI: 10.1039/P19840002919

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