The triethylamine catalyzed reaction of N,N-disubstituted thioamide–bromine adducts with unsubstituted thiobenzamide

Abstract

The reaction of N,N-disubstituted thioamide–bromine adducts with unsubstituted thioamide, followed by treatment with triethylamine, affords novel N′-thiobenzoylamidines along with smaller amounts of secondary products. A mechanism is proposed for the formation of the amidines. The results give an insight into the initial steps of the mechanism by which thioamides are converted into 1,2,4-thiadiazoles.