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Issue 0, 1984
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Asymmetric synthesis using chirally modified borohydrides. Part 2. Enantioselective reduction of ketones with polymeric (S)-prolinol–borane reagent

Abstract

Chiral polymeric reagents have been prepared from polymeric (S)-prplinols and borane and used in the enantioselective reduction of a series of prochiral ketones under various conditions. Reductions with these polymeric reagents are shown to give alcohols of reasonably good optical purity (up to 80%). The results are compared to those obtained with (S)-N-benzylprolinol–borane complex which is a soluble model reagent.

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Article type: Paper
DOI: 10.1039/P19840002887
Citation: J. Chem. Soc., Perkin Trans. 1, 1984, 2887-2893
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    Asymmetric synthesis using chirally modified borohydrides. Part 2. Enantioselective reduction of ketones with polymeric (S)-prolinol–borane reagent

    S. Itsuno, K. Ito, A. Hirao and S. Nakahama, J. Chem. Soc., Perkin Trans. 1, 1984, 2887
    DOI: 10.1039/P19840002887

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