Treatment of the racemic disubstituted pent-4-enals (1) and (2) at ca. 150 °C with the chiral complex [Rh(chiraphos)2]Cl [chiraphos = 2S,3S-bis(diphenylphosphino)butane] results in a cyclisation reaction and catalytic asymmetric synthesis of the 2,2- and 3,3-disubstituted cyclopentanones (3) and (4), respectively.
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Journal of the Chemical Society, Chemical Communications
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