Biosynthesis of austalide D, a meroterpenoid mycotoxin from Aspergillus ustus
Abstract
Incorporation of [1-13C]- and [1,2-13C2]-acetate, and (3RS)-[2-13C]mevalonate into austalide D, a metabolite of Aspergillus ustus, and the isolation of the cometabolites austalide J, K, and L, indicate its formation via a mixed polyketide–terpenoid biosynthetic pathway.