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Issue 21, 1982
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A direct preparation of acetyl-(S)-phenylalanyl-(S)-phenylalanine methyl ester by a double asymmetric hydrogenation

Abstract

Acetyl-(S)-phenylalanyl-(S)-phenylalamine methyl ester [Ac(S)Phe(S)PheOMe] is obtained with high diastereoselectivity and enantioselectivity by catalytic hydrogenation, using [Rh(dipamp)(cod)]+BF4(dipamp =R,R-1,2-bis[(2-Methoxypheny) phenylphosphino] ethane, cod = cyclo-octa-1,5-diene) as chiral catalyst, of a substrate containing two prochiral doubly bonded carbon atoms, which is easily available from glycine and benzaldehyde.

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Article type: Paper
DOI: 10.1039/C39820001261
Citation: J. Chem. Soc., Chem. Commun., 1982, 1261-1262
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    A direct preparation of acetyl-(S)-phenylalanyl-(S)-phenylalanine methyl ester by a double asymmetric hydrogenation

    J. Poulin and H. B. Kagan, J. Chem. Soc., Chem. Commun., 1982, 1261
    DOI: 10.1039/C39820001261

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