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Issue 15, 1979
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Asymmetric synthesis of (R)-α-phenylalkylamines via alkylation of chiral hydrazones by Grignard reagents

Abstract

Chiral hydrazones, obtained by the condensation of (–)-N-aminoephedrine with aryl aldehydes, reacted with Grignard reagents to give chiral hydrazines in almost 100% diastereomeric excess, which were hydrogenolysed to give (R)-α-phenylalkylamines and ephedrine hydrochloride in extremely high enantiomeric excess.

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Article type: Paper
DOI: 10.1039/C39790000668
Citation: J. Chem. Soc., Chem. Commun., 1979, 668-669
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    Asymmetric synthesis of (R)-α-phenylalkylamines via alkylation of chiral hydrazones by Grignard reagents

    H. Takahashi, K. Tomita and H. Otomasu, J. Chem. Soc., Chem. Commun., 1979, 668
    DOI: 10.1039/C39790000668

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