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Microbiological hydroxylation of steroids. Part XI. Convenient routes to 3,7-, 3,11-, 3,12-, 7,11-, 7,17-, and 11,17-dioxygenated 5α-androstanes and to 5α-androstan-11-one

Alan M. Bell,  Virginia E. M. Chambers, Mrs.,  Sir Ewart,  R. H. Jones,  G. Denis Meakins,  Wilhelm E. Müller  and  John Pragnell 

Abstract

Suitable, readily available 3,17-dioxygenated 5α-androstanes are hydroxylated efficiently at position 11 by Aspergillus ochraceus and at position 7 by Rhizopus nigricans. These reactions, carried out on a reasonable scale, are the basis of convenient routes to derivatives of 5α-androstane (3,7-, 3,11-, 3,12-, 7,11-, 7,17-, and 11,17-dioxygenated compounds, and 5α-androstan-11-one) which are not readily accessible by chemical means.

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Article type: Paper
DOI: 10.1039/P19740000312
Citation: J. Chem. Soc., Perkin Trans. 1, 1974,0, 312-317
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    Microbiological hydroxylation of steroids. Part XI. Convenient routes to 3,7-, 3,11-, 3,12-, 7,11-, 7,17-, and 11,17-dioxygenated 5α-androstanes and to 5α-androstan-11-one

    A. M. Bell, V. E. M. Chambers, S. Ewart, R. H. Jones, G. D. Meakins, W. E. Müller and J. Pragnell, J. Chem. Soc., Perkin Trans. 1, 1974, 0, 312
    DOI: 10.1039/P19740000312

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