Raman optical activity of bromocamphor solutions

Abstract

Solutions of (+)-3-bromocamphor in CH₂Cl₂ and (–)-3-bromocamphor-π-sulphonic acid in H₂O show similar Raman circular intensity differential bands between 800 and 930 cm^–1, but with opposite signs, that probaly originate in vibrations of the skeleton in the vicinity of the bromine atom; this indicates that Raman optical activity can correlate absolute configurations by directly probing the appropriate parts of the molecular framework.