Issue 26, 2017

Improving the brightness and photostability of NIR fluorescent silica nanoparticles through rational fine-tuning of the covalent encapsulation methods

Abstract

Near-infrared (NIR) fluorescence imaging technology calls for highly bright and photostable emissive materials for long-term and real-time bioimaging and medical diagnosis. Herein, we report that four aminocyanine dyes were covalently encapsulated inside silica nanoparticles by reverse microemulsion using different linkage methods. The fluorescence brightness and photostability of the obtained fluorescent silica nanoparticles (FSNPs) were found to have direct correlation with the used covalent encapsulation methods, especially the number of anchoring sites of the encapsulated dyes. The aminocyanine dye 4-Si contains three anchoring sites for embedding into the silica nanoparticles, and provides FSNP-4 – the FSNP with the best brightness and photostability.

Graphical abstract: Improving the brightness and photostability of NIR fluorescent silica nanoparticles through rational fine-tuning of the covalent encapsulation methods

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
29 Mar 2017
Accepted
02 Jun 2017
First published
02 Jun 2017

J. Mater. Chem. B, 2017,5, 5278-5283

Improving the brightness and photostability of NIR fluorescent silica nanoparticles through rational fine-tuning of the covalent encapsulation methods

L. Jiao, F. Song, B. Zhang, H. Ning, J. Cui and X. Peng, J. Mater. Chem. B, 2017, 5, 5278 DOI: 10.1039/C7TB00856B

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