SCHEDULED MAINTENANCE
Ni(ii)-Catalyzed enantioselective Mukaiyama–Mannich reaction between silyl enol ethers and cyclic N-sulfonyl α-ketiminoesters†
Abstract
The enantioselective Mukaiyama–Mannich reaction of cyclic N-sulfonyl α-ketiminoesters and silyl enol ethers was realized for the first time using a Ni(II)-bis(oxazoline) complex. Both di- and tri-substituted silyl enol ethers as well as silyl dienol ethers generated from the corresponding aromatic ketones or α,β-unsaturated ketones were well tolerated in this reaction. The reaction proceeded smoothly under mild conditions to provide a series of enantioenriched benzofused sultams containing an α-quaternary α-amino ester and an aromatic ketone moiety. Moreover, the products can be readily converted into potentially bioactive benzosultams including aziridine and polycyclic benzosultams.
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