Issue 23, 2017
From the journal:

Chemical Communications

Enzyme-responsive reporter molecules for selective localization and fluorescence imaging of pathogenic biofilms†

Junxin Aw,a   Frances Widjaja, ORCID logo a   Yichen Ding,bc   Jing Mu,a   Yang Liangb  and  Bengang Xing ORCID logo *ad  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, Singapore
E-mail: bengang@ntu.edu.sg

b Centre for Environmental Life Sciences Engineering (SCELSE), School of Biological Sciences, Nanyang Technological University, Singapore, Singapore

c Interdisciplinary Graduate School (IGS), Nanyang Technological University, Singapore

d Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

Abstract

Pathogenic bacteria and their biofilm formation are responsible for a broad spectrum of microbial infections. A novel enzyme-responsive reporter molecule (ERM-1), which can specifically recognize AmpC β-lactamase (Bla) in drug resistant bacteria, has been developed to enable the selective localization of biofilms.

Graphical abstract: Enzyme-responsive reporter molecules for selective localization and fluorescence imaging of pathogenic biofilms

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Article information

DOI
https://doi.org/10.1039/C6CC09296A
Article type
Communication
Submitted
21 Nov 2016
Accepted
22 Dec 2016
First published
22 Dec 2016

Chem. Commun., 2017,53, 3330-3333

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Enzyme-responsive reporter molecules for selective localization and fluorescence imaging of pathogenic biofilms

J. Aw, F. Widjaja, Y. Ding, J. Mu, Y. Liang and B. Xing, Chem. Commun., 2017, 53, 3330 DOI: 10.1039/C6CC09296A

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