* Corresponding authors

^a State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, Jiangsu Key laboratory of drug design and optimization, China Pharmaceutical University, Nanjing 210009, China
E-mail: jiyea@cpu.edu.cn

^b College of Engineering, Peking University, Beijing 100871, China
E-mail: xiaolei_wu@pku.edu.cn

^c Center for Drug Safety Evaluation and Research, Shanghai University of Traditional Chinese Medicine, China

^d Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China

^e Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond, Virginia, USA