Volume 173, 2014
From the journal:

Faraday Discussions

Water-soluble fullerene materials for bioapplications: photoinduced reactive oxygen species generation

Yoko Yamakoshi,*ab   Safwan Aroua,ab   Thach-Mien Duong Nguyen,b   Yuko Iwamotoa  and  Tsuyoshi Ohnishic  

* Corresponding authors

a Laboratorium für Organische Chemie, ETH-Zürich, Vladimir-Prelog-Weg 3, CH8093 Zürich, Switzerland
E-mail: yamakoshi@org.chem.ethz.ch

b Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA19104, USA

c Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia PA19104, USA

Abstract

The photoinduced reactive oxygen species (ROS) generation from several water-soluble fullerenes was examined. Macromolecular or small molecular water-soluble fullerene complexes/derivatives were prepared and their 1O2 and O2˙− generation abilities were evaluated by ESR spin-trapping methods. As a result, efficient 1O2 generation was detected from photoexcited C60, not only in organic solvents, but also in aqueous media and especially from small molecule C60–carboxylic acid derivatives. Whereas efficient O2˙− generation was observed in the aqueous solution of the C60/γ-CD complex under photoirradiation.

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Article information

DOI
https://doi.org/10.1039/C4FD00076E
Article type
Paper
Submitted
23 Apr 2014
Accepted
16 May 2014
First published
16 May 2014

Faraday Discuss., 2014,173, 287-296

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Water-soluble fullerene materials for bioapplications: photoinduced reactive oxygen species generation

Y. Yamakoshi, S. Aroua, T. D. Nguyen, Y. Iwamoto and T. Ohnishi, Faraday Discuss., 2014, 173, 287 DOI: 10.1039/C4FD00076E

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