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New J. Chem., 2007, 31, 1996 - 2014, DOI: 10.1039/b712012e
Applications of tripodal [S3] and [Se3] L2X donor ligands to zinc, cadmium and mercury chemistry: organometallic and bioinorganic perspectives
Gerard Parkin
The tripodal tris(2-mercapto-1-R–imidazolyl)hydroborato ligand system, [TmR], and its selenium counterpart, [TseR], provide useful platforms for investigating organometallic and bioinorganic aspects of the chemistry of zinc, cadmium and mercury in sulfur-rich and selenium-rich coordination environments. For example, the tridentate [TmR] ligand provides an [S3] donor array that is of use for mimicking aspects of zinc enzymes and proteins that have sulfur-rich active sites, such as the Ada DNA repair protein. With respect to mercury, an interesting application of the [TmBut] ligand is the synthesis of the mercury alkyl compounds [TmBut]HgR (R = Me, Et) that react with PhSH to yield [TmBut]HgSPh and RH, a reaction that emulates mercury detoxification by the organomercurial lyase, MerB. In addition to the tridentate [TmR] and [TseR] ligands, applications of the bidentate counterparts, [BmR] and [BseR] are also described.
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