RSC Publishing


Publishing

 

Cover image for Chemical Communications, select for current issue

Chemical Communications

Urgent high quality communications from across the chemical sciences.



Subscribers

Non-subscribers

Free access



Feature Article

Chem. Commun., 2009, 6145 - 6158, DOI: 10.1039/b913411e

Amide-based bifunctional organocatalysts in asymmetric reactions

Xiaohua Liu, Lili Lin and Xiaoming Feng

A series of amide-based bifunctional organocatalysts have been utilized in asymmetric reactions. Prolinamide analogues have been designed to catalyze asymmetric reactions via enamine intermediates with the assistance of tunable hydrogen bonding. In addition, the combination of various Lewis base functional groups, such as guanidine, N-oxide and phosphane, with an amide moiety have also constituted efficient bifunctional organocatalysts with unique reactivity and selectivity.

Graphical abstract image for this article (ID: b913411e)