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Chem. Commun., 2009, 4944 - 4946, DOI: 10.1039/b911612e

Phosphabarrelene-modified Rh-catalysts: a new and selective route towards hydroxy-functionalized bicyclic imidazoles via tandem reactions

Patrick S. Bäuerlein, Ismael Arenas Gonzalez, Jarno J. M. Weemers, Martin Lutz, Anthony L. Spek, Dieter Vogt and Christian Müller

8-Hydroxy-6-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine was formed selectively in high yields from N-(-methallyl)imidazole by a tandem hydroformylation–cyclization sequence, representing a novel one-pot catalytic synthesis of bicyclic imidazole derivatives.

Graphical abstract image for this article (ID: b911612e)