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Chem. Commun., 2009, 3931 - 3933, DOI: 10.1039/b907290j

Nickel/AlMe2Cl-catalysed carbocyanation of alkynes using arylacetonitriles

Akira Yada, Tomoya Yukawa, Yoshiaki Nakao and Tamejiro Hiyama

Nickel/Lewis acid dual catalysis was found to effect the carbocyanation reaction of alkynes using arylacetonitriles, giving a range of triply substituted acrylonitriles; the reaction of optically active -phenylpropionitrile suggested a reaction mechanism that involves oxidative addition of a C–CN bond with retention of its absolute configuration.

Graphical abstract image for this article (ID: b907290j)