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Chem. Commun., 2009, 3910 - 3912, DOI: 10.1039/b902878a

Rhodium catalyzed enantioselective cyclization of substituted imidazoles via C–H bond activation

Andy S. Tsai, Rebecca M. Wilson, Hitoshi Harada, Robert G. Bergman and Jonathan A. Ellman

The enantioselective intramolecular alkylation of substituted imidazoles with enantiomeric excesses up to 98% has been accomplished by rhodium catalyzed C–H bond functionalization with (S,S,R,R)TangPhos as the chiral ligand.

Graphical abstract image for this article (ID: b902878a)