Issue 44, 2012

Structure–function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS

Abstract

2-Heptyl-3-hydroxy-4-quinolone (PQS) and its precursor 2-heptyl-4-quinolone (HHQ) are key signalling molecules of the important nosocomial pathogen Pseudomonas aeruginosa. We have recently reported an interkingdom dimension to these molecules, influencing key virulence traits in a broad spectrum of microbial species and in the human pathogenic yeast Candida albicans. For the first time, targeted chemical derivatisation of the C-3 position was undertaken to investigate the structural and molecular properties underpinning the biological activity of these compounds in P. aeruginosa, and using Bacillus subtilis as a suitable model system for investigating modulation of interspecies behaviour.

Graphical abstract: Structure–function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS

Supplementary files

Article information

Article type
Paper
Submitted
12 Jun 2012
Accepted
26 Sep 2012
First published
26 Sep 2012

Org. Biomol. Chem., 2012,10, 8903-8910

Structure–function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS

F. J. Reen, S. L. Clarke, C. Legendre, C. M. McSweeney, K. S. Eccles, S. E. Lawrence, F. O'Gara and G. P. McGlacken, Org. Biomol. Chem., 2012, 10, 8903 DOI: 10.1039/C2OB26823J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements