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Issue 8, 2016
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Bioinformatics for the synthetic biology of natural products: integrating across the Design–Build–Test cycle

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Abstract

Covering: 2000 to 2016

Progress in synthetic biology is enabled by powerful bioinformatics tools allowing the integration of the design, build and test stages of the biological engineering cycle. In this review we illustrate how this integration can be achieved, with a particular focus on natural products discovery and production. Bioinformatics tools for the DESIGN and BUILD stages include tools for the selection, synthesis, assembly and optimization of parts (enzymes and regulatory elements), devices (pathways) and systems (chassis). TEST tools include those for screening, identification and quantification of metabolites for rapid prototyping. The main advantages and limitations of these tools as well as their interoperability capabilities are highlighted.

Graphical abstract: Bioinformatics for the synthetic biology of natural products: integrating across the Design–Build–Test cycle

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Publication details

The article was received on 05 Feb 2016 and first published on 17 May 2016


Article type: Highlight
DOI: 10.1039/C6NP00018E
Citation: Nat. Prod. Rep., 2016,33, 925-932
  • Open access: Creative Commons BY license
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    Bioinformatics for the synthetic biology of natural products: integrating across the Design–Build–Test cycle

    P. Carbonell, A. Currin, A. J. Jervis, N. J. W. Rattray, N. Swainston, C. Yan, E. Takano and R. Breitling, Nat. Prod. Rep., 2016, 33, 925
    DOI: 10.1039/C6NP00018E

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