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Issue 83, 2016
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Visible-light-mediated generation of nitrile oxides for the photoredox synthesis of isoxazolines and isoxazoles

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Abstract

Visible-light photoredox catalysis enables the synthesis of biologically relevant isoxazolines and isoxazoles from hydroxyimino acids. The process shows broad functional group compatibility and mechanistic and computational studies support a visible-light-mediated generation of nitrile oxides by two sequential oxidative single electron transfer processes.

Graphical abstract: Visible-light-mediated generation of nitrile oxides for the photoredox synthesis of isoxazolines and isoxazoles

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Publication details

The article was received on 21 Jul 2016, accepted on 21 Sep 2016 and first published on 21 Sep 2016


Article type: Communication
DOI: 10.1039/C6CC06029C
Citation: Chem. Commun., 2016,52, 12302-12305
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    Visible-light-mediated generation of nitrile oxides for the photoredox synthesis of isoxazolines and isoxazoles

    T. D. Svejstrup, W. Zawodny, J. J. Douglas, D. Bidgeli, N. S. Sheikh and D. Leonori, Chem. Commun., 2016, 52, 12302
    DOI: 10.1039/C6CC06029C

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