Metal-free [3+2] cycloaddition of azides with Tf2C![[double bond, length as m-dash]](https://www.rsc.org/images/entities/char_e001.gif)
CH2 for the regioselective preparation of elusive 4-(trifluoromethylsulfonyl)-1,2,3-triazoles†
Abstract
1,2-Dipole Tf2CCH2 is generated in situ and immediately reacts at room temperature with an azide to afford previously unknown 4-trifluoromethanesulfonyl 1,2,3-triazoles through a stepwise [3+2] cycloaddition reaction. Noteworthily, this mild and powerful uncatalyzed protocol is highly regio- and chemoselective.
![Graphical abstract: Metal-free [3+2] cycloaddition of azides with Tf2C [[double bond, length as m-dash]] CH2 for the regioselective preparation of elusive 4-(trifluoromethylsulfonyl)-1,2,3-triazoles](/En/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C5CC01223F&imageInfo.ImageIdentifier.Year=2015)
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![[double bond, length as m-dash]](https://www.rsc.org/images/entities/h2_char_e001.gif)
CH2 for the regioselective preparation of elusive 4-(trifluoromethylsulfonyl)-1,2,3-triazoles
