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Issue 8, 2014
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Copper-catalyzed trifluoromethylation of N-arylacrylamides “on water” at room temperature

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Abstract

A copper-catalyzed intramolecular trifluoromethylation of arylacrylamides leads to oxindole derivatives, effected with stable and inexpensive Langlois' reagent (CF3SO2Na). These reactions proceed via a radical process in water at room temperature. The aqueous solution can be recycled.

Graphical abstract: Copper-catalyzed trifluoromethylation of N-arylacrylamides “on water” at room temperature

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Publication details

The article was received on 23 Oct 2013, accepted on 08 Nov 2013 and first published on 11 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC48131J
Citation: Chem. Commun., 2014,50, 936-938
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    Copper-catalyzed trifluoromethylation of N-arylacrylamides “on water” at room temperature

    F. Yang, P. Klumphu, Y. Liang and B. H. Lipshutz, Chem. Commun., 2014, 50, 936
    DOI: 10.1039/C3CC48131J

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