Issue 3, 2013
From the journal:

Chemical Science

Biomimetic syntheses and structural elucidation of the apoptosis-inducing sesquiterpenoid trimers: (−)-ainsliatrimers A and B†

Chao Li,a   Ting Dong,b   Longyang Dian,a   Weidong Zhangc  and  Xiaoguang Lei*ab  

* Corresponding authors

a College of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China

b National Institute of Biological Sciences, Beijing (NIBS), Changping District, Beijing, China
E-mail: leixiaoguang@nibs.ac.cn
Fax: +86-10-80704785

c Department of Phytochemistry, Second Military Medical University, Shanghai, China

Abstract

Ainsliatrimers A and B are two recently isolated complex sesquiterpenoid natural products that display the unprecedented chemical motifs and remarkable anti-cancer activities. The exact structures as well as the mechanism of anti-cancer action for ainsliatrimers A and B remain to be elucidated. Here we report the first concise and biomimetic syntheses of (−)-ainsliatrimers A and B. Our synthetic endeavor ultimately enabled the unambiguous structural assignments for these two stunningly complex trimers. Preliminary biological studies also revealed that ainsliatrimers A and B significantly inhibited cancer cell growth by inducing apoptosis.

Graphical abstract: Biomimetic syntheses and structural elucidation of the apoptosis-inducing sesquiterpenoid trimers: (−)-ainsliatrimers A and B

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Article information

DOI
https://doi.org/10.1039/C2SC22023G
Article type
Edge Article
Submitted
20 Nov 2012
Accepted
19 Dec 2012
First published
19 Dec 2012

Chem. Sci., 2013,4, 1163-1167

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Biomimetic syntheses and structural elucidation of the apoptosis-inducing sesquiterpenoid trimers: (−)-ainsliatrimers A and B

C. Li, T. Dong, L. Dian, W. Zhang and X. Lei, Chem. Sci., 2013, 4, 1163 DOI: 10.1039/C2SC22023G

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