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Issue 35, 2012
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Zr- and Hf-based nanoscale metal–organic frameworks as contrast agents for computed tomography

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Abstract

Nanoscale metal–organic frameworks (NMOFs) of the UiO-66 structure containing high Zr (37 wt%) and Hf (57 wt%) content were synthesized and characterized, and their potential as contrast agents for X-ray computed tomography (CT) imaging was evaluated. Hf-NMOFs of different sizes were coated with silica and poly(ethylene glycol) (PEG) to enhance biocompatibility, and were used for in vivo CT imaging of mice, showing increased attenuation in the liver and spleen.

Graphical abstract: Zr- and Hf-based nanoscale metal–organic frameworks as contrast agents for computed tomography

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Publication details

The article was received on 12 Apr 2012, accepted on 07 Jun 2012 and first published on 07 Jun 2012


Article type: Paper
DOI: 10.1039/C2JM32299D
Citation: J. Mater. Chem., 2012,22, 18139-18144
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    Zr- and Hf-based nanoscale metal–organic frameworks as contrast agents for computed tomography

    K. E. deKrafft, W. S. Boyle, L. M. Burk, O. Z. Zhou and W. Lin, J. Mater. Chem., 2012, 22, 18139
    DOI: 10.1039/C2JM32299D

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