Issue 35, 2015

Micrometer-sized network structure of novel DNA–lipid conjugates induced by heat stimulation

Abstract

We have developed a novel lipid-bearing DNA that forms hairpin modules, including a single RNA monomer; this can be used to create micrometer-sized structures from nanometer-sized building blocks during breakage at the RNA site. In the presence of divalent metal ions and heat stimulation, we observed transition of the self-assembly, which results in the formation of a three-dimensional network structure. To our knowledge, this is also the first report of heat-induced micrometer-sized molecular self-assembly of molecules that carry biological information.

Graphical abstract: Micrometer-sized network structure of novel DNA–lipid conjugates induced by heat stimulation

Supplementary files

Article information

Article type
Paper
Submitted
11 Jun 2015
Accepted
25 Jul 2015
First published
07 Aug 2015

Soft Matter, 2015,11, 7053-7058

Author version available

Micrometer-sized network structure of novel DNA–lipid conjugates induced by heat stimulation

K. Takahashi, M. Matsuo, T. Banno and T. Toyota, Soft Matter, 2015, 11, 7053 DOI: 10.1039/C5SM01456E

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