Jump to main content
Jump to site search

Issue 112, 2016, Issue in Progress
Previous Article Next Article

SBA-15 mesoporous silica particles loaded with cisplatin induce senescence in B16F10 cells

Author affiliations

Abstract

The anticancer drug cisplatin (CP) is loaded into SBA-15 mesoporous silica (SBA-15|CP) and its release from the nanomaterial is studied. The CP-loaded SBA-15 is tested against four tumor cell lines: mouse malignant melanoma B16F10, human adenocarcinoma HeLa, colon HT-29 and prostate PC3. Most importantly, the superiority of this novel material in comparison to CP arises from the fact that the CP-grafted nanomaterial SBA-15 (→SBA-15|CP) is enhancing cessation of proliferation along with induction of senescence in B16F10 in approximately 3.5 times lower concentration. The control material loaded with therapeutically inactive K2[PtCl4] (→SBA-15|TC) showed no antitumor activity. To a large extent, SBA-15|CP-induced senescence might present a safe approach in tumor treatment. Such cells can be cleared by immune cells resulting in efficient tumor regression. So far only apoptotic agents are being exploited in clinics, thus an understanding of the chemotherapeutic-induced senescence will allow oncologists to explore this essential tumor suppressor mechanism.

Graphical abstract: SBA-15 mesoporous silica particles loaded with cisplatin induce senescence in B16F10 cells

Back to tab navigation

Publication details

The article was received on 09 Sep 2016, accepted on 11 Nov 2016 and first published on 15 Nov 2016


Article type: Paper
DOI: 10.1039/C6RA22596A
Citation: RSC Adv., 2016,6, 111031-111040
  •   Request permissions

    SBA-15 mesoporous silica particles loaded with cisplatin induce senescence in B16F10 cells

    D. Edeler, M. R. Kaluđerović, B. Dojčinović, H. Schmidt and G. N. Kaluđerović, RSC Adv., 2016, 6, 111031
    DOI: 10.1039/C6RA22596A

Search articles by author

Spotlight

Advertisements