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Issue 26, 2014
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Flash carboxylation: fast lithiation–carboxylation sequence at room temperature in continuous flow

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Abstract

A method for the direct lithiation of terminal alkynes and heterocycles with subsequent carboxylation in a continuous flow format was developed. This method provides carboxylic acids at ambient conditions within less than five seconds with only little excess of the organometallic base and CO2.

Graphical abstract: Flash carboxylation: fast lithiation–carboxylation sequence at room temperature in continuous flow

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Publication details

The article was received on 19 Feb 2014, accepted on 28 Feb 2014 and first published on 03 Mar 2014


Article type: Communication
DOI: 10.1039/C4RA01442A
Citation: RSC Adv., 2014,4, 13430-13433
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    Flash carboxylation: fast lithiation–carboxylation sequence at room temperature in continuous flow

    B. Pieber, T. Glasnov and C. O. Kappe, RSC Adv., 2014, 4, 13430
    DOI: 10.1039/C4RA01442A

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