Issue 26, 2014

Flash carboxylation: fast lithiation–carboxylation sequence at room temperature in continuous flow

Abstract

A method for the direct lithiation of terminal alkynes and heterocycles with subsequent carboxylation in a continuous flow format was developed. This method provides carboxylic acids at ambient conditions within less than five seconds with only little excess of the organometallic base and CO2.

Graphical abstract: Flash carboxylation: fast lithiation–carboxylation sequence at room temperature in continuous flow

Supplementary files

Article information

Article type
Communication
Submitted
19 Feb 2014
Accepted
28 Feb 2014
First published
03 Mar 2014

RSC Adv., 2014,4, 13430-13433

Flash carboxylation: fast lithiation–carboxylation sequence at room temperature in continuous flow

B. Pieber, T. Glasnov and C. O. Kappe, RSC Adv., 2014, 4, 13430 DOI: 10.1039/C4RA01442A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements