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Issue 77, 2014
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COSAN as a molecular imaging platform: synthesis and “in vivo” imaging

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Abstract

A labelling method for the covalent attachment of radioiodine to the boron-rich 8-I-cobaltabisdicarbollide (I-COSAN) and a bi-functional (iodine and PEG) COSAN derivative, [3,3′-Co(8-I-1,2-C2B9H10)(8′-(OCH2CH2)2COOC6H5-1′,2′-C2B9H10)], is reported. Biodistribution studies in rodents using dissection/gamma counting and in vivo nuclear imaging have been performed. The general strategy reported here can be applied in the future to COSAN derivatives bearing a wide range of functionalities.

Graphical abstract: COSAN as a molecular imaging platform: synthesis and “in vivo” imaging

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Publication details

The article was received on 02 Jul 2014, accepted on 31 Jul 2014 and first published on 31 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC05058D
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2014,50, 11415-11417
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    COSAN as a molecular imaging platform: synthesis and “in vivo” imaging

    K. B. Gona, A. Zaulet, V. Gómez-Vallejo, F. Teixidor, J. Llop and C. Viñas, Chem. Commun., 2014, 50, 11415
    DOI: 10.1039/C4CC05058D

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