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Issue 5, 2014
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Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

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Abstract

We develop a quantum dot based DNA nanosensor specifically targeting the cleavage–religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy.

Graphical abstract: Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

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Publication details

The article was received on 03 Oct 2013, accepted on 04 Nov 2013 and first published on 05 Nov 2013


Article type: Communication
DOI: 10.1039/C3RA45557B
Citation: RSC Adv., 2014,4, 2491-2494
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    Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

    M. L. Jepsen, A. Ottaviani, B. R. Knudsen and Y. Ho, RSC Adv., 2014, 4, 2491
    DOI: 10.1039/C3RA45557B

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