Issue 30, 2017
From the journal:

RSC Advances

Organocatalytic synthesis of enantioenriched 1,2,4-triazolines containing a chiral quaternary carbon center†

Li-Jun Zhang,a   Si-Xiang Zhang,a   Li-Na Fu,a   Xiao-Yun Lia  and  Qi-Xiang Guo ORCID logo *a  

* Corresponding authors

a Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing, China
E-mail: qxguo@swu.edu.cn

Abstract

An efficient asymmetric cyclization reaction of amino-acid-derived isothiocyanates with azodicarboxylates is described. The chiral 1,2,4-triazolines are prepared in good yield (up to 87%) and enantioselectivities (up to 95% ee).

Graphical abstract: Organocatalytic synthesis of enantioenriched 1,2,4-triazolines containing a chiral quaternary carbon center

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Article information

DOI
https://doi.org/10.1039/C6RA28800F
Article type
Paper
Submitted
29 Dec 2016
Accepted
22 Mar 2017
First published
28 Mar 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 18714-18717

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Organocatalytic synthesis of enantioenriched 1,2,4-triazolines containing a chiral quaternary carbon center

L. Zhang, S. Zhang, L. Fu, X. Li and Q. Guo, RSC Adv., 2017, 7, 18714 DOI: 10.1039/C6RA28800F

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