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Issue 11, 2017
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Click-based functionalization of a 2′-O-propargyl-modified branched DNA nanostructure

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Abstract

DNA has emerged as a versatile building block for programmable self-assembly. DNA-based nanostructures have been widely applied in biosensing, bioimaging, drug delivery, molecular computation and macromolecular scaffolding. A variety of strategies have been developed to functionalize these nanostructures. In this study, we report a facile click-based strategy to incorporate a metal chelating ligand and a fluorescent tag into a three-point-star DNA tile containing 2′-O-propargyl groups. Such a strategy opens up the possibility of functionalizing pre-assembled DNA strands to construct platforms for metal or drug delivery.

Graphical abstract: Click-based functionalization of a 2′-O-propargyl-modified branched DNA nanostructure

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Publication details

The article was received on 17 Dec 2016, accepted on 17 Feb 2017 and first published on 20 Feb 2017


Article type: Communication
DOI: 10.1039/C6TB03277J
Citation: J. Mater. Chem. B, 2017,5, 2074-2077
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    Click-based functionalization of a 2′-O-propargyl-modified branched DNA nanostructure

    V. Valsangkar, A. R. Chandrasekaran, R. Wang, P. Haruehanroengra, O. Levchenko, K. Halvorsen and J. Sheng, J. Mater. Chem. B, 2017, 5, 2074
    DOI: 10.1039/C6TB03277J

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