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Issue 7, 2017
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Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement

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Abstract

Acquiring a divergent response from homologous protein domains is essential for selective ligand–protein interactions. Stereospecific fluorination of (−)-balanol, an ATP mimic, uncovers a new source of selectivity from integrated chemical and conformational perturbation that differentiates homologous sites by the level of congruency in their response to local and remote fluorine effects.

Graphical abstract: Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement

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Publication details

The article was received on 07 Nov 2016, accepted on 18 Jan 2017 and first published on 24 Jan 2017


Article type: Communication
DOI: 10.1039/C7OB00129K
Citation: Org. Biomol. Chem., 2017,15, 1570-1574
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    Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement

    A. R. Patel, A. Hardianto, S. Ranganathan and F. Liu, Org. Biomol. Chem., 2017, 15, 1570
    DOI: 10.1039/C7OB00129K

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