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Issue 5, 2017
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Multi-step continuous-flow synthesis

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Organic chemistry is continually evolving to improve the syntheses of value added and bioactive compounds. Through this progression, a concomitant advancement in laboratory technology has occurred. Many researchers now choose to mediate transformations in continuous-flow systems given the many benefits over round bottom flasks. Furthermore, reaction scale up is often less problematic as this is addressed at the inception of the science. Although single-step transformations in continuous-flow systems are common, multi-step transformations are more valuable. In these systems, molecular complexity is accrued through sequential transformations to a mobile scaffold, much like an in vitro version of Nature's polyketide synthases. Utilizing this methodology, multi-step continuous-flow systems have improved the syntheses of active pharmaceutical ingredients (APIs), natural products, and commodity chemicals. This Review details these advancements while highlighting the rapid progress, benefits, and diversification of this expanding field.

Graphical abstract: Multi-step continuous-flow synthesis

  • This article is part of the themed collection: Primer
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Publication details

The article was received on 21 Nov 2016 and first published on 20 Jan 2017

Article type: Tutorial Review
DOI: 10.1039/C6CS00830E
Citation: Chem. Soc. Rev., 2017,46, 1250-1271
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    Multi-step continuous-flow synthesis

    J. Britton and C. L. Raston, Chem. Soc. Rev., 2017, 46, 1250
    DOI: 10.1039/C6CS00830E

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