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Issue 69, 2016
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Rapid screening of copper intermediates in Cu(I)-catalyzed azide–alkyne cycloaddition using a modified ICP-MS/MS platform

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Abstract

Rapid screening of Cu+-intermediates by using 63Cu+ or 65Cu+ ions as catalysts with or without ligand protection in Cu(I)-catalyzed azide–alkyne cycloaddition was realized using an on-line modified ICP-MS/MS platform in this work, while the Cu+-intermediates without ligand protection are very active, which are extremely difficult to be observed using other existing techniques. This universal platform was suitable to study the mechanism of organic reactions catalyzed by unstable metal(I) ions as well as to discover new candidates for metal(I) catalysts.

Graphical abstract: Rapid screening of copper intermediates in Cu(i)-catalyzed azide–alkyne cycloaddition using a modified ICP-MS/MS platform

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Publication details

The article was received on 08 Jun 2016, accepted on 28 Jul 2016, published on 28 Jul 2016 and first published online on 28 Jul 2016


Article type: Communication
DOI: 10.1039/C6CC04793A
Citation: Chem. Commun., 2016,52, 10501-10504
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    Rapid screening of copper intermediates in Cu(I)-catalyzed azide–alkyne cycloaddition using a modified ICP-MS/MS platform

    Q. He, Z. Xing, C. Wei, X. Fang, S. Zhang and X. Zhang, Chem. Commun., 2016, 52, 10501
    DOI: 10.1039/C6CC04793A

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