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Issue 16, 2016
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Nanoscale silicon surface-assisted laser desorption/ionization mass spectrometry: environment stability and activation by simple vacuum oven desiccation

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Abstract

Nanoscale silicon surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is an emerging matrix-free, highly sensitive MS analysis method. An important challenge in using nanoscale silicon SALDI-MS analysis is the aging and stability of silicon after storage in various environments. No proper nanoscale silicon SALDI-MS activation procedure has been reported to solve this issue. This study investigated the sensitivity, wettability, and surface oxidation behavior of nanoscale silicon surface SALDI-MS in a room, an inert gas atmosphere, and a vacuum environment. A simple vacuum oven desiccation was proposed to activate the SALDI-MS surface, and the limit of detection was further enhanced 1000 times to a 500 attomole level using this approach. The long-term stability and desorption/ionization mechanism were also investigated.

Graphical abstract: Nanoscale silicon surface-assisted laser desorption/ionization mass spectrometry: environment stability and activation by simple vacuum oven desiccation

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Publication details

The article was received on 19 Mar 2016, accepted on 10 Jun 2016 and first published on 13 Jun 2016


Article type: Paper
DOI: 10.1039/C6AN00659K
Citation: Analyst, 2016,141, 4973-4981
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    Nanoscale silicon surface-assisted laser desorption/ionization mass spectrometry: environment stability and activation by simple vacuum oven desiccation

    C. Tsao, Y. Lin, P. Chen, Y. Yang and S. H. Tan, Analyst, 2016, 141, 4973
    DOI: 10.1039/C6AN00659K

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